CZS-241

Overview

CZS-241 is an orally active and selective inhibitor of Polo-like Kinase (PLK) 4 ( IC 50 =2.6 nM). CZS-241 inhibits TRKA with an IC 50 value of 2.74 μM. CZS-241 induces apoptosis and arrests cell cycle at S/G2 phase. CZS-241 shows highly potent antiproliferative activity against leukemia cell lines, and exhibits safety against normal cell lines.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > Trk Receptor | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-149912
• CAS No.: 3016297-55-2
• Molecular Formula: C26H24ClF2N9O
• Molecular Weight: 551.98
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source