A2AR-antagonist-1

Overview

A2AR-antagonist-1 (compound 38) is an orally active adenosine A2A receptor (A2AR) antagonist ( IC 50 =29 nM). A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability (t 1/2 =86.1 min). A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules ( LAG-3 and TIM-3 ) and enhancing effector molecules (GZMB, IFNG, and IL-2 ).

Application

Products | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Adenosine Receptor

Product Information

• Catalog No.: HY-149916
• CAS No.: 2922920-71-4
• Molecular Formula: C27H25N5O2
• Molecular Weight: 451.52
• Purity: 96.68%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source