Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC 50 s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2 , respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
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