MS8511 hydrochloride

Overview

MS8511 (hydrochloride) is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC 50 values of 100 nM (G9a) and 140 nM (GLP), and K d values of 44 nM (G9a) and 46 nM (GLP). MS8511 (hydrochloride) reduces the cellular H3K9me2 level and enhances antiproliferation activity. MS8511 (hydrochloride) can be used for the research of several types of cancers including brain, breast, ovarian, lung, bladder, melanoma, colorectal cancer , and other disease such as Alzheimer’s disease (AD), sickle cell disease, Prader−Willi syndrome (PWS).

Application

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Product Information

• Catalog No.: HY-150510A
• CAS No.: 3031788-28-7
• Molecular Formula: C28H42ClN5O3
• Molecular Weight: 532.12
• Purity: 98.07%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source