Everafenib

Overview

Everafenib is a potent and blood-brain barrier (BBB) penetrant BRAF inhibitor, also inhibits MAPK signaling. Everafenib has inhibitory activity against a panel of V600E BRAF melanoma cell lines with IC 50 values of 2-10 nM, which is better than Dabrafenib ( HY-14660 ) and Vemurafenib ( HY-12057 ). Everafenib has efficacy in an intracranial mouse model of metastatic melanoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Raf

Product Information

• Catalog No.: HY-150639
• CAS No.: 2923700-82-5
• Molecular Formula: C20H23ClFN5O2S2
• Molecular Weight: 484.01
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source