JAK-IN-23

Overview

JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB . JAK-IN-23 can inhibit JAK1/2/3 with IC 50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC 50 values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD).

Application

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Product Information

• Catalog No.: HY-151262
• CAS No.: 3031837-35-8
• Molecular Formula: C23H22Cl2N4O
• Molecular Weight: 441.35
• Purity: 98.88%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source