RUNX1/ETO tetramerization-IN-1

Overview

RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor of RUNX1/ETO tetramerization , exhibits anti-leukemic effect. RUNX1/ETO tetramerization-IN-1 specifically targets to NHR2 of RUNX1/ETO ( EC 50 =0.25 μM), restores gene expression down-regulated by RUNX1/ETO . RUNX1/ETO tetramerization-IN-1 inhibits the proliferation of RUNX1/ETO -depending SKNO-1 cells, and reduces the RUNX1/ETO -related tumor growth in a mouse model.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > RUNX

Product Information

• Catalog No.: HY-151411
• CAS No.: 88755-39-9
• Molecular Formula: C18H14O7
• Molecular Weight: 342.30
• Purity: 99.36%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (7.30 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source