TK-129

Overview

TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC 50 =44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B -associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease .

Application

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Product Information

• Catalog No.: HY-151483
• CAS No.: 3031476-73-7
• Molecular Formula: C15H23N5O2
• Molecular Weight: 305.38
• Purity: ≥98.0%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution
• Availability: In-stock

Source

Original product source