Ritlecitinib tosylate

Overview

Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor ( IC 50 =33 nM) without inhibitory activity towards JAK1 , JAK2 , and TYK2 (IC 50 >10 μ M). Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15 . Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE).

Application

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Product Information

• Catalog No.: HY-100754C
• CAS No.: 2192215-81-7
• Molecular Formula: C22H27N5O4S
• Molecular Weight: 457.55
• Purity: 99.65%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source