Ipatasertib

Overview

Ipatasertib (GDC-0068) is an orally active, highly selective and ATP-competitive pan- Akt inhibitor with IC 50 values of 5, 18, 8 nM for Akt1/2/3 , respectively. Ipatasertib synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models.

Application

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Product Information

• Catalog No.: HY-15186
• CAS No.: 1001264-89-6
• Molecular Formula: C24H32ClN5O2
• Molecular Weight: 458.00
• Purity: 99.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 5 mg/mL (10.92 mM); Clear solution
• Availability: In-stock

Source

Original product source