Ipatasertib tosylate

Overview

Ipatasertib (GDC-0068) tosylate is an orally active, highly selective and ATP-competitive pan- Akt inhibitor with IC 50 values of 5, 18, 8 nM for Akt1/2/3 , respectively. Ipatasertib tosylate synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib tosylate also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models.

Application

Products | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Organoid | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-15186C
• CAS No.: 1491138-24-9
• Molecular Formula: C31H40ClN5O5S
• Molecular Weight: 630.20
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source