EMD638683 (S-Form)

Overview

EMD638683 (S-Form) (Compound 1a), the S-enantiomer of EMD638683 ( HY-15193 ), is a SGK1 inhibitor with an IC 50 value > 300 nM. EMD638683 is an orally active SGK1 inhibitor with an IC 50 of 3 μM. EMD638683 exhibits strong inhibition against SGK1 , moderate inhibition against SGK2 and SGK3 , and shows excellent selectivity for other AGC kinase family members. EMD638683 has antihypertensive activity by inhibiting SGK1 , and independently of the blood pressure-lowering effect, it effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/ IL-1β axis. EMD638683 promotes apoptosis of colon cancer cells and sensitizes radiotherapy. EMD638683 (S-Form) can be used in research related to hypertension, hypertensive heart damage, and colon cancer .

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Others | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SGK | Products > Signaling Pathways > Drug Isomer

Product Information

• Catalog No.: HY-15193B
• CAS No.: 1184940-46-2
• Molecular Formula: C18H18F2N2O4
• Molecular Weight: 364.34
• Purity: 99.72%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.75 mg/mL (7.55 mM); Clear solution
• Availability: In-stock

Source

Original product source