CUR5g

Overview

CUR5g is a potent autophagy inhibitor. CUR5g selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g blocks the recruitment of STX17 to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g improves the anticancer effect of Cisplatin ( HY-17394 ) against A549 cells both in vitro and in vivo.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-152100
• CAS No.: 1370032-20-4
• Molecular Formula: C22H20N2O2
• Molecular Weight: 344.41
• Purity: 98.69%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution
• Availability: In-stock

Source

Original product source