BPDA2 is a highly selective and competitive active site SHP2 inhibitor with IC 50 s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2 , SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes.
Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Signaling Pathways > SHP1 | Products > Signaling Pathways > SHP2
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