DDO3711

Overview

DDO3711, a PP5-recruiting phosphatase recruitment chimeras (PHORCs), is formed by connecting a small molecular apoptosis signal-regulated kinase 1 ( ASK1 ) inhibitor to a PP5 activator through a chemical linker. DDO3711 specifically inhibits ASK1 ( IC 50 =164.1 nM) not ASK2 (IC 50 >20 μM). DDO3711 significantly dephosphorylates p-ASK1 T838 by recruiting PP5 and shows the ASK1-dependent antiproliferative activity. DDO3711 has anti-cancer activity and has the potential for abnormally phosphorylated oncoproteins research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MAP3K

Product Information

• Catalog No.: HY-152247
• CAS No.: 2673364-10-6
• Molecular Formula: C42H41N9O6
• Molecular Weight: 767.83
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source