Copanlisib dihydrochloride

Overview

Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC 50 s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα , PI3Kδ , PI3Kβ and PI3Kγ , respectively. Copanlisib dihydrochloride has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR . Copanlisib dihydrochloride has superior antitumor activity.

Application

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Product Information

• Catalog No.: HY-15346A
• CAS No.: 1402152-13-9
• Molecular Formula: C23H30Cl2N8O4
• Molecular Weight: 553.44
• Purity: 99.55%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: 100 mg/mL (180.69 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source