Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor ( IC 50 s: 6.2 μM and 4.2μM for SIRT1 and SIRT2 , respectively). Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma.
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