NISC-6 is a novel dual Topo-IIα/Akt inhibitor. NISC-6 has inhibitory activity against various cells, such as UACC903 ( IC 50 = 2.5 µM) and CHL-1 ( IC 50 = 0.8 µM) cells. NISC-6 dose dependently induces early and late apoptosis . NISC-6 can be used for research on melanoma.
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Topoisomerase | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Apoptosis
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