AZ0108

Overview

AZ0108 is an inhibitor for poly ADP-ribose polymerase ( PARP ), which inhibits PARP1 , PARP2 , PARP3 , PARP6, TNKS1, TNKS2, with IC 50 s of <0.03, <0.03, 2.8, 0.083, 3.2, >3 μM, respectively. AZ0108 prevents centrosome clustering with an EC 50 of 0.053 μM, and exhibits cytotoxicity in cell OCI-LY-19 with GI 50 of 0.017 μM. AZ0108 exhibits good in vivo pharmacokinetic characters in rat/mouse models.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PARP

Product Information

• Catalog No.: HY-100847
• CAS No.: 1825345-52-5
• Molecular Formula: C24H20F4N6O2
• Molecular Weight: 500.45
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source