FEN1-IN-7

Overview

FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 ( FEN1 , IC 50 =18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease , xeroderma pigmentosum G ( XPG ) with an IC 50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents.

Application

Products | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > FLAP

Product Information

• Catalog No.: HY-153792
• CAS No.: 824983-90-6
• Molecular Formula: C16H14N2O6S
• Molecular Weight: 362.36
• Purity: 99.93%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: 2.5 mg/mL (6.90 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source