GSK-3 inhibitor 3

Overview

GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3 , with IC 50 s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β , respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC 50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research .

Application

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Product Information

• Catalog No.: HY-154851
• CAS No.: 2227279-84-5
• Molecular Formula: C23H15FN6O
• Molecular Weight: 410.40
• Purity: 99.10%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 1.5 mg/mL (3.65 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source