TRAP1-IN-1

Overview

TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1 ，a mitochondrial isoform of Hsp90 . TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94，and disrupts TRAP1 tetramer stability，induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS ，disrupts the mitochondrial membrane potential，and enhances glycolysis metabolism.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HSP | Products > Signaling Pathways > Mitochondrial Metabolism

Product Information

• Catalog No.: HY-155063
• CAS No.: 3031102-94-7
• Molecular Formula: C45H39F7N2O4P2
• Molecular Weight: 866.74
• Purity: 96.03%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 5 mg/mL (5.77 mM); Clear solution
• Availability: In-stock

Source

Original product source