FD274

Overview

FD274 is a highly potent PI3K/mTOR dual inhibitor with IC 50 s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR , respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 arrests HL-60 cell cycle at G1 phase and increases apoptosis . FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research.

Application

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Product Information

• Catalog No.: HY-155066
• CAS No.: 2641899-38-7
• Molecular Formula: C22H14ClFN6O2S
• Molecular Weight: 480.90
• Purity: 99.45%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source