OATD-02

Overview

OATD-02 is an orally active, competitive, reversible, noncovalent dual inhibitor of Arginase1 and 2 . OATD-02 is a slow offset inhibitor, blocking intracellular arginases with IC 50 s of 20 nM ( hARG1 ), 39 nM ( hARG2 ), 39 nM ( mARG1 ), and 28 nM ( rARG1 ), respectively. OATD-02 abolishes tumor immunosuppression induced by both arginases. OATD-02 can be used for melanoma study.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Arginase

Product Information

• Catalog No.: HY-155108
• CAS No.: 2146132-73-0
• Molecular Formula: C12H25BN2O4
• Molecular Weight: 272.15
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source