Anticancer agent 147 (compound 6j) is a derivative of sophoridine ( HY-N1373 ) and is a ferroptosis inducer. Anticancer agent 147 can promote the accumulation of intracellular Fe 2+ , reactive oxygen species (ROS) and MDA, increase ER stress, and upregulate the expression of the activating transcription factor ATF3. Anticancer agent 147 has good anti-liver cancer effects in vitro and in vivo.
Products | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ferroptosis
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