Antiproliferative agent-34

Overview

Antiproliferative agent-34 (Compound A14) is a multi-target kinase inhibitor, with an IC 50 of 177 nM and 1567 nM for EGFR L858R/T790M and EGFR WT . Antiproliferative agent-34 also inhibits JAK2 , ROS1, FLT3 , FLT4, PDGFRα with IC 50 of 30.93, 106.90, 108.00, 226.60, 42.53 nM. Antiproliferative agent-34 inhibits H1975 and HCC827 cells proliferation with IC 50 values below 40 nM under normoxic condition, and the anti-proliferation potency achieves 4–6-fold improvement ( IC 50 values < 10 nM) under hypoxic condition.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-155178
• CAS No.: 2910858-34-1
• Molecular Formula: C27H27N7O5
• Molecular Weight: 529.55
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source