PI3Kδ-IN-16

Overview

PI3Kδ-IN-16 is a potent and selective PI3Kδ inhibitor with an IC 50 value of 0.9 nM. PI3Kδ-IN-16 has a strong anti-proliferative effect on SU-DHL-6 cells, causing cell cycle arrest and inducing apoptosis . PI3Kδ-IN-16 tightly bins to PI3Kδ protein with a planar-shaped conformation. The kinase activity of PI3Kδ-IN-16 which is ~378-fold over PI3Kα , 412-fold over PI3Kβ , and 10-fold over PI3Kγ . PI3Kδ-IN-16 can be used for the study of hematologic malignancies.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-155232
• CAS No.: 2766437-35-6
• Molecular Formula: C22H26N6O2
• Molecular Weight: 406.48
• Purity: 99.02%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution
• Availability: In-stock

Source

Original product source