22-(4′-py)-JA

Overview

22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases ( MMP-2 and MMP-9 ), hypoxia-inducible factor 1α ( HIF-1α ) and vascular endothelial growth factor ( VEGF ). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC).

Application

Products | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > mTOR

Product Information

• Catalog No.: HY-155721
• CAS No.: 1178895-15-2
• Molecular Formula: C32H30N4O8
• Molecular Weight: 598.60
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source