Sirt1/2-IN-2

Overview

Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC 50 s of 1.8 μM ( SIRT1 ) and 2.4 μM ( SIRT2 ), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Sirtuin | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-155727
• CAS No.: 670267-73-9
• Molecular Formula: C18H14N4O3S2
• Molecular Weight: 398.46
• Purity: 90%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source