SHR5428

Overview

SHR5428 is a potent, orally active, selective and noncovalent inhibitor of CDK7 with highly potent CDK7 enzymatic activity ( IC 50 =2.3 nM). SHR5428 inhibits triple negative breast cancer cellular activity on MDA-MB-468 cell ( IC 50 =6.6 nM).

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-155787
• CAS No.: 3054791-71-5
• Molecular Formula: C22H23F3N5O2P
• Molecular Weight: 477.42
• Purity: 99.80%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.24 mM); Clear solution
• Availability: In-stock

Source

Original product source