LYP-IN-3

Overview

LYP-IN-3 is a selective, orally active and reversible lymphoid-tyrosine phosphatase ( LYP ) inhibitor ( IC 50 = 2.55 μM, Ki = 0.93 μM). D34 exhibits high selectivity of PTP1B, PTPN12, PTPN5 and SSH2. LYP-IN-3 regulates the T-cell receptor (TCR) signaling by specifically inhibiting LYP . LYP-IN-3 does not significantly inhibit MC38 cell viability; its anti-tumor effect stems from immune regulation. LYP-IN-3 can significantly upregulate PD-L1 or PD-1 expression in different immune cells. LYP-IN-3 facilitates T-cell infiltration and enhances T-cell functions. LYP-IN-3 synergizes with PD-L1 blockade can significantly improve colorectal tumor regression. LYP-IN-3 can be used for the study of colorectal cancer .

Application

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Product Information

• Catalog No.: HY-155847
• CAS No.: 3052262-64-0
• Molecular Formula: C35H27NO6S
• Molecular Weight: 589.66
• Purity: 99.80%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (4.24 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source