GM-90257

Overview

GM-90257 is a microtubule acetylation inhibitor. GM-90257 binds directly to α-tubulin . GM-90257 prevents the recruitment of α-tubulin acetyltransferase 1 (αTAT1) to the K40 residue in α-tubulin. GM-90257 causes Apoptosis , downregulates BCl-2 , and activates JNK and PARP . GM-90257 has anticancer activity against breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Pain | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Parkinson's Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > JNK | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Microtubule/Tubulin | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Bcl-2 Family

Product Information

• Catalog No.: HY-155956
• CAS No.: 315703-81-2
• Molecular Formula: C16H14N4OS2
• Molecular Weight: 342.44
• Purity: 99.90%
• Storage: -20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1.25 mg/mL (3.65 mM); Clear solution
• Availability: In-stock

Source

Original product source