VEGFR/PARP-IN-1

Overview

VEGFR/PARP-IN-1 (Compound 14b) is a VEGFR/PARP dual inhibitor ( IC 50 s: 191 nM and 60.9 nM respectively). VEGFR/PARP-IN-1 inhibits DNA damage repair, induces cell apoptosis , and arrests cell in the G2/M phase. VEGFR/PARP-IN-1 has good antiproliferative efficacy against BRCA wild-type breast cancer cells ( IC 50 : 4.1 and 3.5 μM for MDA-MB-231 and MCF-7 cells). VEGFR/PARP-IN-1 is an antitumor and anti-metastasis agent.

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PARP

Product Information

• Catalog No.: HY-155965
• CAS No.: 3010256-54-6
• Molecular Formula: C29H27N9O
• Molecular Weight: 517.58
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source