STAT3-IN-20

Overview

STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor ( IC 50 : 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells ( IC 50 : 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis .

Application

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Product Information

• Catalog No.: HY-155982
• CAS No.: 2768427-54-7
• Molecular Formula: C30H27F4N7S
• Molecular Weight: 593.64
• Purity: 99.83%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source