TRK-IN-24

Overview

TRK-IN-24 (compound 10g) is a Trk Receptor inhibitor that inhibits TRKA , TRKC , TRKA G595R , TRKA G667C and TRKA F589L IC 50 s are 5.21, 4.51, 6.77, 1.42 and 6.13 nM respectively. TRK-IN-24 has antitumor efficacy in BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C xenograft models. TRK-IN-24 inhibits the proliferation of Ba/F3 cells transfected with single mutants such as SF, GK, and xDFG, with an IC 50 of 1.43-47.56 nM.

Application

Products | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Trk Receptor

Product Information

• Catalog No.: HY-156086
• CAS No.: 2937544-01-7
• Molecular Formula: C39H45N7O3
• Molecular Weight: 659.82
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source