GDC-0623

Overview

GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (K i =0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC 50 =42 nM) versus A375 (BRAF V600E , EC 50 =7 nM).

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Pain | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Obesity | Products > Disease Areas > Rheumatoid Arthritis | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MEK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-15610
• CAS No.: 1168091-68-6
• Molecular Formula: C16H14FIN4O3
• Molecular Weight: 456.21
• Purity: 98.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.48 mM); Clear solution
• Availability: In-stock

Source

Original product source