HA-100 is a potent protein kinase inhibitor, with IC 50 s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase ( PKG ) , cAMP-dependent protein kinase ( PKA ) , protein kinase C ( PKC ) and MLC-kinase , respectively. HA-100 also used as a ROCK inhibitor.
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