KY386

Overview

KY386 is a DHX33 helicase inhibitor with an IC 50 of 0.019 μM. KY386 inhibits the cell viability of various cancer cells. KY386 induces ferroptosis in cancer cells, and induces apoptosis in some cancer cell lines. KY386 increases the intracellular levels of ROS , LPO and Fe 2+ , and decreases the level of GSH in cancer cells . KY386 inhibits the growth of gastric cancer and colon cancer xenografts in nude mice. KY386 is applicable to the related research on liver cancer , lung cancer , pancreatic cancer , colorectal cancer , gastric cancer , breast cancer , leukemia, renal cancer , prostate cancer , esophageal cancer , cervical cancer , brain cancer (glioblastoma) and melanoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Gastric Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Cervical Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Melanoma | Products > Disease Areas > Esophageal Cancer | Products > Disease Areas > Renal Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-156418
• CAS No.: 2787598-01-8
• Molecular Formula: C21H19N5O2S
• Molecular Weight: 405.47
• Purity: 99.86%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.17 mM); Clear solution
• Availability: In-stock

Source

Original product source