GSK-J4 hydrochloride

Overview

GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC 50 s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC 50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1.

Application

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Product Information

• Catalog No.: HY-15648F
• CAS No.: 1797983-09-5
• Molecular Formula: C24H28ClN5O2
• Molecular Weight: 453.96
• Purity: 99.01%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (4.58 mM); Clear solution
• Availability: In-stock

Source

Original product source