FM19G11 is a hypoxia-inducible factor-1-alpha ( HIF-1α ) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC 50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions.
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