HSD17B13-IN-2

Overview

HSD17B13-IN-2 is an HSD17B13 inhibitor with human IC 50 values of 0.18 μM (with β-estradiol as substrate) and 0.25 μM (with Leukotriene B4 as substrate), and it exhibits selectivity for human HSD17B11 . HSD17B13-IN-2 binds to the active site of HSD17B13 in an NAD + -dependent manner, interacts with the bound NAD + cofactor, and stabilizes human HSD17B13 protein to prevent its aggregation. HSD17B13-IN-2 reduces the conversion of β-estradiol to estrone in cellular assays. HSD17B13-IN-2 can be used in studies related to nonalcoholic fatty liver disease.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > 17β-HSD

Product Information

• Catalog No.: HY-156735
• CAS No.: 863564-24-3
• Molecular Formula: C21H23F2NO4
• Molecular Weight: 391.41
• Purity: 99.72%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.39 mM); Clear solution
• Availability: In-stock

Source

Original product source