MTX-216

Overview

MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR . MTX-216 cosuppresses Ki-67 and ribosomal S6 phosphorylation and induces apoptosis in NF1 LOF cells. MTX-216 suppresses the activity of SYK kinase, with an IC 50 of 281 nM. MTX-216 is used in the research of Melanoma.

Application

Products | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > Syk | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-156872
• CAS No.: 1952236-19-9
• Molecular Formula: C22H14Cl2FN5O2S
• Molecular Weight: 502.35
• Purity: 99.98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.98 mM); Suspended solution
• Availability: In-stock

Source

Original product source