CRT0066101 trihydrochloride

Overview

CRT0066101 trihydrochloride is the trihydrochloride salt form of CRT0066101 ( HY-15698 ). CRT0066101 trihydrochloride is an orally active PKD inhibitor with IC 50 values of 1 nM, 2.5 nM and 2 nM for PKD1 , PKD2 , and PKD3 , respectively. CRT0066101 trihydrochloride is also an inhibitor for PIM2 with an IC 50 of ~135.7 nM. CRT0066101 trihydrochloride exhibits anti-inflammatory activity in mice LPS ( HY-D1056 )-induced lung injury models, and has anticancer effects.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Signaling Pathways > PKD | Products > Signaling Pathways > Pim | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-15698B
• CAS No.: 1781742-22-0
• Molecular Formula: C18H25Cl3N6O
• Molecular Weight: 447.79
• Purity: 99.23%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2 mg/mL (4.47 mM); Clear solution
• Availability: In-stock

Source

Original product source