PI3Kα-IN-14

Overview

PI3Kα-IN-14 (compound F8) is a selective PI3Kα inhibitor with an IC 50 of 0.14 nM. PI3Kα-IN-14 induces a great decrease in mitochondrial membrane which caused cell cycle arrest at G1 phase and apoptosis in U87-MG cells. PI3Kα-IN-14 shows significant anti-proliferative activities against three tumor-derived cell lines (PC-3: IC 50 of 0.28 μM; HCT-116: IC 50 of 0.57 μM; and U87-MG: IC 50 of 1.37 μM).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-157125
• CAS No.: 3026856-46-9
• Molecular Formula: C28H29ClF2N10O4
• Molecular Weight: 643.04
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source