HC-5404-Fu

Overview

HC-5404-Fu is an orally active PERK inhibitor with an IC 50 of 0.001 μM against human PERK . HC-5404-Fu blocks PERK activation induced by VEGFR-TKI and disrupts the adaptive stress response triggered by VEGFR-TKI . HC-5404-Fu enhances anti-angiogenic effects by inhibiting newly formed and mature tumor blood vessels in renal cell carcinoma models. HC-5404-Fu can be used in research related to renal cell carcinoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Metastatic Breast Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PERK

Product Information

• Catalog No.: HY-157231A
• CAS No.: 3034479-99-4
• Molecular Formula: C24H24F2N4O3.1/2C4H4O4
• Molecular Weight: 512.51
• Purity: 98.92%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 5 mg/mL (9.76 mM); Clear solution
• Availability: In-stock

Source

Original product source