Vercirnon sodium

Overview

Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9 . Vercirnon sodium inhibits CCR9-mediated Ca 2+ mobilization and chemotaxis on Molt-4 cells with IC 50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC 50 s>10 μM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC 50 values of 2.8 and 2.6 nM, respectively.

Application

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Product Information

• Catalog No.: HY-15724A
• CAS No.: 886214-18-2
• Molecular Formula: C22H20ClN2NaO4S
• Molecular Weight: 466.91
• Purity: 98.04%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: 5 mg/mL (10.71 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source