UNC8153 TFA

Overview

UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2) -targeted degrader with a K d of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein ( DC 50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark . UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2.

Application

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Product Information

• Catalog No.: HY-157251
• CAS No.: 2929304-61-8
• Molecular Formula: C35H38F3N5O7
• Molecular Weight: 697.70
• Purity: 99.92%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (3.58 mM); Clear solution
• Availability: In-stock

Source

Original product source