UNC8153

Overview

UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2) -targeted degrader with a K d of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein ( DC 50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark . UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-157251A
• CAS No.: 2929304-60-7
• Molecular Formula: C33H37N5O5
• Molecular Weight: 583.68
• Purity: 99.61%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source