AKE-72

Overview

AKE-72 (compound 5) is a potent inhibitor of Pan-BCR-ABL . AKE-72 inhibits BCR-ABL WT , BCR-ABL T315 , BCR-ABL E255K , BCR-ABL F3171 , BCR-ABL H396P and BCR-ABL Q252H with IC 50 s of < 0.5, 9, 8.98, 3.12, < 1.0 and 3.88 nM, respectively. AKE-72 has anti-leukemic activity against K-562 cell line.

Application

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Product Information

• Catalog No.: HY-157327
• CAS No.: 2566525-18-4
• Molecular Formula: C30H29F3N6O
• Molecular Weight: 546.59
• Purity: 98.29%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution
• Availability: In-stock

Source

Original product source