AGI-6780

Overview

AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2 R140Q with IC 50 of 23±1.7 nM. AGI-6780 is less potent against IDH2 WT with IC 50 of 190±8.1 nM.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Isocitrate Dehydrogenase (IDH)

Product Information

• Catalog No.: HY-15734
• CAS No.: 1432660-47-3
• Molecular Formula: C21H18F3N3O3S2
• Molecular Weight: 481.51
• Purity: 99.26%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution
• Availability: In-stock

Source

Original product source